31 Mahabir et al. indicated that Snail increased the synthesis of MMP-9 and vimentin in malignant glioma cell lines.26 Taki et al. demonstrated that there was a correlation between Snail and CXCR4 levels in human OSCC.8 In line with these findings, we detected that Snail-1 knockdown culminate in a remarkable reduction in metastasis-related genes, such as vimentin, MMP-9, and CXCR4. This evidence concerns the gene CXCR4 and malignant glioma.