Transforming of epithelial cells into migratory mesenchymal cells is described as EMT, which is the main process mediating chronic inflammation, embryonic growth, and fibrosis, as well as the tumor progression.15-18 A bulk of studies has established that Slug/Snail zinc-finger proteins increase the invasive and migratory behaviors of cancer cell through suppressing the adhesive characteristic of epithelial cells.19-21 Therefore, Snail can be considered as one of the appealing targets for the progression of pharmaceutical elements. This evidence concerns the gene ZNF146 and cancer.