Therefore, an antibody-mediated PD-L1 blockade in cancer cells inhibited the AKT/mTOR signaling pathway, resulting in the reduced translation of mRNAs encoding glycolytic enzymes.89 The same results were achieved by silencing PD-L1, strongly suggesting that PD-L1 itself was the modulator of glycolysis in cancer cells. The gene discussed is AKT1; the disease is cancer.