We recently published a study to identify intracellular signaling motifs in PD-L1 and their relevance in cancer cell growth and resistance to interferons.25 Hence, to identify potential signal motifs within the intracytoplasmic terminus of PD-L1, we undertook a classical approach by comparing 10 mammalian PD-L1 molecules.25 Three well-conserved sequence motifs were identified, termed “RMLDVEKC”, “DTSSK”, and “QFEET” according to the most representative conserved residues25 (Fig. 2a). Here, CD274 is linked to cancer.