It was found that 11 genes (PIK3R3, PIK3CG, MAPK8, GSK3B, ITGB1, CDKN1A, PTK2, VEGFA, PRKACB, RAP1B, and RAP1A) with five pathways (pathways in cancer, focal adhesion, proteoglycans in cancer, PI3K-Akt signaling pathway, and Ras signaling pathway) are involved and considered more likely to play a role as influential agents. This evidence concerns the gene PIK3R3 and cancer.