Notably, the mRNA level of SIGLEC5 was significantly enhanced for the HF/n-3 mice compared to control and HF mice (Fig. 6e) and, within the HF/n-3 group, SIGLEC5 was significantly correlated with the gene expression levels of EMR1, MCR1 and CLEC10a, and even UCP1 (Additional file 1: Table S8). Here, ADGRE1 is linked to hydrops fetalis.