TP53 and acute myeloid leukemia: TP53 mutations, which occur in ~5–8% of all patients with AML [22, 23], are more frequently observed in older patients (21% of patients in the current study) and patients with abnormalities of chromosomes 5, 7, or 17p, are associated with complex karyotype, and generally indicate a poor prognosis in hematologic malignancies regardless of treatment choice [3, 22, 24–29].