Studies in AML of azacitidine in combination with the BCL2 inhibitor, venetoclax (ClinicalTrials.gov NCT03466294), the mutant IDH inhibitors, enasidenib and ivosidenib (NCT02677922), and the mutant FLT3 inhibitors, gilteritinib (NCT02752035) and quizartinib (NCT01892371), are currently ongoing. The gene discussed is IDH2; the disease is acute myeloid leukemia.