Sox2 expression was strongly and highly significantly (p < 0.0001) up-regulated in tumors versus normal and tumor-adjacent mucosa (median IHC score of 150 in tumors versus 0 in normal and tumor-adjacent mucosa), whereas vimentin expression showed a moderate induction in tumor-adjacent mucosa and tumors as compared to normal mucosa (p < 0.0001) (Fig. 1d). Here, SOX2 is linked to neoplasm.