We replicated GWAS reported 9 SNPs (KCNN3, PRRX1, CAV1, C9orf3, HCN4, ZFHX3, PITX2, SYNE2, SYNPO2L)3 and compared allele frequencies of these SNPs between AF patients and non-AF controls (Supplementary Table S1). This evidence concerns the gene HCN4 and atrial fibrillation.