The most highly differentially expressed genes (log2(fold change) >3; E+GSCs vs. E-GBM+NSPCs analysis) with enriched TEAD-accessible chromatin peaks corresponded to WNT, Cadherin, EGFR, and metabolism-related signaling pathways, many of them previously implicated in tumor invasion18, and included EGFR, CDH4, TNC, AQP4, ETV1, ITGA7, ENO1, PCDHGC5, NRCAM, PTPRZ1, ACSBG1, MEOX2, OSMR, and ACSS3 (Supplementary Fig. 6a–b). This evidence concerns the gene PCDHGC5 and glioblastoma.