To this end, transcriptome analysis of primary GBM samples defined STAT3 and C/EBPβ as master regulators of mesenchymal transformation29, a behavior typically associated with increased tumor infiltration and GBM recurrence; and ZEB1 was found to be significantly overexpressed in infiltrative vs. non-infiltrative glioma lesions22. The gene discussed is STAT3; the disease is glioblastoma.