An in vivo experiment carried out on BDL rats showed that the melatonin administration reduces liver fibrosis and serum cytokine levels for IL-1β and IL-6 [47], but it has recently been shown that melatonin administration inhibits GnRH secretion and reduces bile duct hyperplasia and liver fibrosis in BDL rats [48]. Here, GNRH1 is linked to Hepatic fibrosis.