In a previous study of ATGL- or HSL-deficient animal models, the absence of ATGL and, to lesser degree, HSL reduces fatty acid mobilization and adipose tissue loss, leading to maintained skeletal muscle mass, suggesting that excessive depletion of adipose tissue may be involved in the progression of skeletal muscle atrophy [29]. The gene discussed is PNPLA2; the disease is Skeletal muscle atrophy.