CTCFL and cancer: Data from the online platform MethHC comparing the methylation status of CTCFL promoters in various cancers with the status of these promoters in corresponding normal tissues disclose that compared with normal corresponding tissues, several common cancers such as carcinomas of the bladder, clear cell kidney, and squamous carcinomas of the lung, head, and neck display hypomethylation of CTCFL promoter (Figure 8a–d).