Here, we extended our recent study by generating keratinocyte-specific IL-4Rα-deficient mice on a BALB/c genetic background (KRT14cre IL-4Rα−/lox mice) to analyze disease progression and host immune responses following infection with the L. major strain IL-81 (a highly virulent strain) as well as LV39 (less virulent strain). Here, IL4R is linked to infection.