Following high-dose infection with L. major IL-81 and LV39 promastigotes subcutaneously in the footpad, footpad swelling, parasite burden, IFN-γ/IL-4/IL-13 cytokine production, and type 1 and type 2 antibody responses were similar between KRT14cre IL-4Rα−/lox and littermate control IL-4Rα−/lox BALB/c mice. The gene discussed is IL4; the disease is infection.