Compounds 10d and 10j not only demonstrated strong antiproliferation activities against some of the tested cancer cell lines, but also showed significant inhibitory activity towards EGFR (IC50 = 29.3 nM and 61.5 nM, respectively) compared to the medicinally important EGFR inhibitor, Gefitinib (IC50 = 33.1 nM). The gene discussed is EGFR; the disease is cancer.