He could induce apoptotic cell death in LoVo and breast cancer cells through regulation of the mitochondrial apoptosis pathway [18,19], as well as evoke apoptosis in cisplatin-resistant head and neck cancer cells by inhibiting the nuclear factor erythroid-2-related factor 2/antioxidant responsive element (Nrf2–ARE) pathway [15]. The gene discussed is NFE2L2; the disease is head and neck cancer.