PRKAA1 and acute myeloid leukemia: Other evidence for AMPK implication in myeloid cell differentiation comes from additional experiments performed in U937 and HEL acute myeloid leukemia (AML) cell lines, in which low doses of cytarabine were found to trigger the autophagy necessary for myeloid differentiation, as shown by increased expression of CD11b and morphologic features of differentiation.