CML accounts for 15–20% of all cases of leukemia in adults [75] and is due to the t(9;22)(q34;q11) translocation, which encodes for the chimeric protein p210 BCR-ABL, a constitutively activated tyrosine kinase [76]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.