In addition, phlorotannins have been shown to exert a number of other biological activities, including the inhibition of α-amylase, α-glucosidase and lipase, which are key enzymes in obesity and diabetes control, as well as angiotensin converting enzyme (ACE); i.e., a specific target for hypertension management [16,17]. The gene discussed is ACE; the disease is obesity due to melanocortin 4 receptor deficiency.