Our observations are consistent with other proposed changes in diet through which consuming pulse-rich foods can decrease hypercholesterolemia, including decreased intakes of dietary cholesterol and trans fats; higher intake of low-GI foods and subsequent increase in insulin sensitivity; higher intakes of protective nutrients such as minerals, folate, and antioxidant compounds, such as tannins, flavonoids, polyphenols, phytates, lectins, and saponins [19,50,55,62]. This evidence concerns the gene INS and familial hypercholesterolemia.