In conclusion, in a diet intervention without prescribed energy restriction, where aerobic exercise was part of a healthy lifestyle program, and health counselling was provided, a pulse-based diet may be more effective than the TLC diet for improving insulin response to an OGTT, levels of TG, LDL-C, HDL-C, TC/HDL-C ratio, and diastolic blood pressure, which can be translated to improved cardio-metabolic and DM2 risk profiles in women with PCOS. This evidence concerns the gene INS and polycystic ovary syndrome.