ALOX5 and asthma: Leukotrienes (LTs), produced through the human 5-LOX pathway, are mediators for allergy and asthma, while cysteinyl leukotrienes (CysLTs), the metabolites of LTs, are known to sustain bronchoconstriction, hypersecretion of mucus, and airway edema, which can trigger asthma [5,6,7].