NPPB and hydrops fetalis: Prevention of heart failure (HF) was also explored in the PREDIMED, but while levels of HF prognostic biomarkers (i.e., NT-proBNP) were reduced in the MedDiet groups in one analysis [54], incidence of new-onset HF was not lower in the MedDiet groups than the control group, perhaps due to a small number of events making the study likely underpowered to investigate the effects on new-incident HF [55].