Recently, it was also reported that a non-proliferative class of HCC characterized by well-differentiated and low-aggressive phenotype consists of two subclasses characterized by gene expression patterns similar to perivenous and periportal hepatocytes, denoted as perivenous (PV) type and periportal (PP) type, respectively; the former shows frequent CTNNB1 mutation and the latter is associated with wild-type CTNNB1 [31]. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.