Furthermore, the anti-VEGFR2 antibody, ramucirumab, is reportedly beneficial to HCC patients with serum alpha-fetoprotein (AFP) levels ≥400 ng/dL, and cabozantinib, that mainly inhibits tyrosine kinases including MET, AXL, VEGFR-2, is also known to induce objective tumor response with reduction of tumor markers [7,8]. This evidence concerns the gene AFP and hepatocellular carcinoma.