CTNNB1 and hepatocellular carcinoma: Although the PP-type of HCC with wild-type CTNNB1 is characterized by low risk of metastatic recurrence, tumors with wild-type CTNNB1 also include proliferative type of HCC, such as those showing cancer extracellular matrix (ECM) remodeling/epithelial mesenchymal transition and stem cell (STEM) phenotype.