Subsequently, we calculated the sum of the Z scores of Alu, LINE-1, and SAT2. A receiver operating characteristic (ROC) curve revealed the sum of Z-scores, “−0.01217,” as the best threshold to discriminate significant global hypomethylation from non-hypomethylation phenotype in the HCC cohort of liver resection. This evidence concerns the gene SAT2 and hepatocellular carcinoma.