As has been reported, HN protected neurons against Aβ, okadaic acid-induced neurotoxicity, as well as mutational APP, PS1, and PS2-induced neuronal death [18,25,26] in vitro, and also exerts neuroprotection in the model of AD and myocardial ischemia–reperfusion (I/R) injury in vivo [27,28]. This evidence concerns the gene APP and Alzheimer disease.