Among transcription factors, NF-κB has important roles in neuroblastoma chemo-resistance as doxorubicin and VP16 have both been shown to trigger NF-κB activation in neuroblastoma cells, inhibiting apoptosis [49]; nevertheless, siMYCN (siRNA against MYCN) has been found to increase caspase-3 mediated apoptosis [50]. This evidence concerns the gene CASP3 and neuroblastoma.