MAPT and early-onset autosomal dominant Alzheimer disease: Abnormal tau aggregation and microtubule destabilization are key in pathological events in multiple neurodegenerative disorders (i.e., Alzheimer’s disease, frontotemporal dementia with parkinsonism-17 (FTDP-17), corticobasal degeneration, Pick’s disease, etc.)classified as tauopathies [4,5].