In contrast, when the above clones were intraperitoneally injected in nude mice, the final tumor weight of the METCAM/MUC18-expressing BG-1 clone was significantly decreased in comparison to that of the empty vector control clone, indicating that increased METCAM/MUC18 expression significantly decreased in vivo tumorigenesis of BG-1 cells [24]. The gene discussed is MCAM; the disease is neoplasm.