VEGFA and neoplasm: The three most famous examples are: TGF-β, which is context dependent, since it behaves as a tumor suppressor in the early stage of tumorigenesis but as a progression promoter in the late stage [7], VEGF, which acts a dual role in tumor progression dependent upon the levels of its expression and the context and timing of its modulation [39] and c-myc, which is modulated by different partners to act a dual role in tumor progression [40].