One possible reason may be that due to the malignancy of the BG-1cell line, which was established from a poorly differentiated adenocarcinoma [24], is not as advanced as the SK-OV-3 cell line, which was established from malignant ascites metastasized from an adenocarcinoma [23]; thus BG-1 cells may require additionally altered physiological conditions to manifest the effect of huMETCAM/MUC18 (human METCAM/MUC18). This evidence concerns the gene MCAM and adenocarcinoma.