Although O-GlcNAcylation of FASN in adipocytes has not been reported to date, given the fact that O-GlcNAc modification is involved in development of insulin resistance and glucose-toxicity in adipocytes [102,103], it is possible that adipocyte FASN is also regulated by O-GlcNAcylation. The gene discussed is FASN; the disease is Insulin resistance.