CXCL8 and neoplasm: Most common migration stimuli rely on cells sensing (by specific G protein-coupled receptors) local gradients in the concentration of chemical factors (chemoattractants) [9] present in the tumor microenvironment (for instance chemokines IL-8 or CXCL12), or certain growth factors, including the platelet-derived growth factor (PDGF) that plays an important role in tumor metastasis [10].