Notably, because of their voltage dependence and much lower Ca2+ sensitivity, the KCa1.1 channels, also highly expressed in GBM cells, could not be activated under these conditions, even at the peak Ca2+ concentration of the oscillations ([13], but see [52] for a case in which the KCa1.1 channel activity may control Ca2+ influx). The gene discussed is KCNMA1; the disease is glioblastoma.