ERN1 and infection: Furthermore, diminishing the function of these genes, bli-3 [39,55,56,57,58,60], ire-1 [34,74,75], trf-1 [34,76], and nsy-1 [77,78], leads to susceptibility to pathogen infections and to oxidative stress, whereas activating BLI-3 redox signaling to SKN-1 enables protection against pathogen infection [55] and oxidative stress [13].