Recently, it has also been demonstrated that Sterol regulatory element-binding protein 1 (SREBP1)—an important transcriptional regulator of lipogenesis [44], regulated by Sec23A [45]—is involved in the modulation of insulin resistance and in the lipogenesis that is chronically enhanced diabetes, thus laying the foundation for the development of novel future therapeutic strategies to contain the onset of diabetes. Here, INS is linked to diabetes mellitus.