NS5A binds to and sequesters nucleosome assembly protein 1-like 1 (NAP1L1), another protein involved in chromatin remodeling, thereby impairing RIG-I and Toll-like receptor 3 (TLR3) responsiveness and possibly contributing to chronic infection and the development of HCC [139]. This evidence concerns the gene NAP1L1 and hepatocellular carcinoma.