Hypermethylation of other important cancer-related genes, including p16, APC, p73, p14, p15, O6MGMT, IGF2, SOCS-1, Gadd45, and STAT1 have also been observed in HCV infection and were shown to be useful in prediction of HCC occurrence and survival [134,135,136,137,138]. The gene discussed is APC; the disease is hepatocellular carcinoma.