Shu et al. [77] demonstrated the abilities of RNA-based nanotechnology in mice, using RNA nanoparticles with an 8-nt sequence corresponding to the seed region of the MicroRNA MiR-21, incorporated into pRNA-3WJ core and an epidermal growth factor receptor (EGFR) targeting aptamer which facilitates RNA nanoparticles’ internalization into cancer cells. The gene discussed is EGFR; the disease is cancer.