Based on the reports of an anti-hypertrophic role of VDR signalling in cardiomyocytes [22–24] and our own data linking VDR deficiency with endothelial dysfunction [19], we hypothesised that VDR deficiency would have a detrimental effect on cardiac function post-MI. The gene discussed is VDR; the disease is hyperinsulinemic hypoglycemia, familial, 4.