The anti-apoptotic actions by which BAG3 protects cells from apoptotic cell death have been shown to be processed via stabilization of anti-apoptotic BCL-2 family members (BCL-2, BCL-XL, and MCL-1) in colon cancer RKO cells [43,44] as well as via direct interaction with pro-apoptotic BAX to attenuate its mitochondrial translocation in glioblastoma cells [45]. This evidence concerns the gene BCL2 and colonic neoplasm.