ESR1 and diabetes mellitus: Particularly, after subcutaneous administrated resveratrol at the dose of 10 mg/kg or 17β-estradiol at the dose of 0.1 mg/kg or 1 mg/kg, an obvious protection from hyperglycemia and a delaying onset of diabetes appeared in STZ-induced diabetic mice, but the doses of 0.1 mg/kg and 1 mg/kg resveratrol had no obvious anti-hyperglycemic effect, which probably involves the lower affinity of resveratrol combined with estrgenα-receptor (ERα) than that of estradiol.