DF patients (those who did not develop any plasma leakage throughout their illness) had a significantly higher IFNγ secretion response (p = 0.02) to the DENV-all peptide pool (median 42.5, IQR = 22.5 to 945 SFU/106 PBMCs), when compared to DHF patients (median 0, IQR = 0 to 12.5 SFU/106 PBMCs) (Fig 1B). This evidence concerns the gene IFNG and dengue disease.