SOAT1 and Insulin resistance: These studies have mostly focused on early-life exposure to antibiotic compounds and reveal that subtherapeutic antibiotic treatment (STAT) of young mice increases adiposity and hormone levels related to metabolism4, transient perturbation of the microbiota by STAT in very early life is sufficient to induce sustained effects on body composition related to obesity16 and that lifelong STAT induces microbiota changes and enhances the adiposity and insulin resistance associated with high-fat diet22.