Early-onset forms of epilepsy such as malignant migrating partial seizures of infancy and autosomal-dominant nocturnal frontal lobe epilepsy can be caused by gf mutations in the slo-2 human homolog Slack/KCNT117,18, which encodes a Na+-gated K+ channel mainly expressed in the brains29. Here, KCNT1 is linked to autosomal dominant nocturnal frontal lobe epilepsy.