Mutants for insulin pathway-related (Chico, Glut1), MODY (maturity onset diabetes of the young) homologs (HNF4, Hex), and glycolysis genes (Hex, Pgi, Pfk, Ald, Pglym78, Eno, and Pyk) showed increased glucose levels relative to controls, ranging from 1.5-fold to 4.5-fold, but variable trehalose levels from low to high (0.7-fold to 1.6-fold) (Fig. 3d, e). This evidence concerns the gene HHEX and maturity-onset diabetes of the young.