To evaluate the in vivo relevance of these findings we analysed freshly isolated BMDMs, which were in vivo conditioned using different treatment schemes: (A) control mice (Cont., no hyperglycaemia), (B) diabetic mice (DM, 22 weeks of persistent hyperglycaemia), and (C) diabetic mice, in which blood glucose levels were normalized for 6 weeks after 16 weeks of persistent hyperglycaemia using the SGLT2-inhbitor dapagliflozin (DM-NG). Here, SLC5A2 is linked to Hyperglycemia.