APOE and Hyperglycemia: To gain insights into specific pathomechanisms of hyperglycaemia versus hyperlipidaemia-induced atherosclerotic plaque development we directly compared hyperglycaemic (induced by low-dose streptozotocin, STZ injection for 5 days, a model of type 1 DM) and hyperlipidaemic (induced by a high-fat diet, HFD) ApoE−/− mice with control ApoE−/− mice.