TNF and Hyperglycemia: Yet, we are confident that the observed changes largely reflect hyperglycaemia-dependent effects as the endpoints analysed (e.g., p66Shc expression and its sequelae: ROS generation, CD36, IL-6, TNFα-expression) were increased in the hyperglycaemic milieu compared to the hyperlipidaemic milieu despite lower total cholesterol levels in the hyperglycaemic milieu.