In fact, similar to what was reported for fasting37, bypassing the duodenum, the whole jejunum and the initial tract of the ileum, duodenal–jeujunal bypass drastically reduces the gut mucosa that enters into contact with gut microbiota’s stress mediator products, resulting in a reduced secretion of HSP70 and GRP78 in response to a high-fat/high-carbohydrate diet with a striking improvement of insulin resistance. The gene discussed is HSPA5; the disease is Insulin resistance.