PLIN2 and metabolic dysfunction-associated steatotic liver disease: Plin2 median fluorescence intensity (MFI) in PBMCs (Fig. 3e) and in HepG2 (Fig. 3f) significantly increased after stimulation with serum of obese IR, NAFLD subjects before metabolic surgery (PBMCs: 54.1 ± 9.55 vs. 97.67 ± 4.0, P = 0.010; HepG2 68.40 ± 1.33 vs. 86.20 ± 2.78, P = 0.003).