To assess the relationship between RPL3L and atrial fibrillation further, we tested all 15 low-frequency coding variants in the gene for association with atrial fibrillation after conditioning on p.Ala75Val and c.1167+1G>A (significance threshold = 0.05/15 = 0.0033, Supplementary Table 2). The gene discussed is RPL3L; the disease is atrial fibrillation.