By performing a meta-analysis of atrial fibrillation using samples from deCODE and the UK biobank, focusing on rare and low-frequency coding and splice variants, with follow up in four sample sets from Norway and the US, we discovered three new atrial fibrillation variants in two genes, two in the ribosomal gene RPL3L and one in MYZAP that encodes a component of the cardiac intercalated discs. This evidence concerns the gene MYZAP and atrial fibrillation.