In the previous study14, we performed RNA-Seq analysis (Supplementary Fig. 1), which revealed a complex transcriptome profile for hepatoblastoma including an increase in expression of stem cell markers, a dramatic decrease in expression of hepatocyte markers (CYP family and OCT family), and surprisingly, often includes increases in expression of TSPs found mainly in patients with aggressive liver cancer. Here, PLXNA2 is linked to liver cancer.