To understand if inhibition of PARP1 modifies its interactions with ALCDs within C/EBPα, p53, HNF4α, CUGBP1, and RB genes, as well as with ALCDs of the additional cancer-related genes, we performed ChIP analysis on HepG2 cells treated with 100 μM DPQ. This evidence concerns the gene HNF4A and cancer.