In a recent study that analyses the association between a set of inflammatory biomarkers and progression of CKD in the Chronic Renal Insufficiency Cohort, the authors reported that elevated circulating levels of fibrinogen and TNF-α and decreased serum albumin are linked with the rapid loss of kidney function in patients with CKD, and these markers are independent predictors of CKD progression [32]. This evidence concerns the gene ALB and chronic kidney disease.