HIF1A and colonic neoplasm: SIRT1 deacetylates and inactivates p53 and HIF1A, active liver X receptor proteins, peroxisome proliferator-activated receptor γ, and NFKB1 to promote cell proliferation [29]; RAS signaling, the excessive activation of which is associated with colon cancer initiation, is reported to promote cancer development in diabetes [30].