Especially, it has been reported that Salmonella infection can polarize MΦs toward M2 phenotype that was dependent on the expression of Salmonella pathogenicity island 1 (SPI-1) (Kyrova et al., 2012), the M2 polarization caused by Salmonella infection was different from other bacteria infection that caused MΦ M1 phenotype polarization. Here, SPI1 is linked to Salmonella Infections.