Vasopressin (AVP; arginine vasopressin) immunofluorescence was stronger in progranulin deficient brains in the paraventricular (PVN) and supraoptical nuclei (SON), and GFAP immunoreactivity of astrocytes revealed a strong gliosis within these regions in Grn-/- mice, which is in line with the inherent neurodegenerative disease. The gene discussed is GRN; the disease is neurodegenerative disease.