SQSTM1 and hyperphosphatemia: To reinforce the relevance of the effect of hyperphosphatemia in loss of skeletal muscle, we searched for evidences of senescence markers in the vastus of old mice and found a higher expression of p53 in muscle from old mice together with higher ILK and p62 expression, resembling the results obtained in cultured myoblast exposed to high extracellular phosphate concentration.