APOE and Alzheimer disease: A population-based study published by Wolters et al. revealed that subjects with higher CVMRs were less likely to develop AD (hazard ratio of 0.84) particularly those carrying APOe4 alleles (hazard ratio of 0.77) at 11.5 years of follow-up; these results give clinical usefulness to the measurement of CVMR in healthy individuals at risk [27].