Importantly, analysis of transcriptome data from 497 tumour samples in the TGCA prostate adenocarcinoma (PRAD) cohort identified 13 mRNA isoforms (includingTPD52,TACC2 andNDUFV3) that are differentially regulated in localised prostate cancer relative to normal tissue, and 3 (OSBPL1A,CLK3 andTSC22D3) which change significantly with Gleason grade and  tumour stage. The gene discussed is TACC2; the disease is neoplasm.