In Drosophila type 2 diabetes models can be generated by two different strategies: by downregulating conserved genes working on insulin pathways as for example the insulin receptor InR, the insulin substrate receptor chico/IRS1, Akt1, PI3K, and by feeding flies with a high sugar rich diet (Alfa and Kim, 2016). This evidence concerns the gene IRS1 and type 2 diabetes mellitus.