It has been shown that MeHg can induce the transcription of several genes related to Nrf2 activation including HO-1, NQO-1 [NQO1 NAD(P)H quinone dehydrogenase], GCLC (glutamate-cysteine ligase catalytic subunit) and Nrf2 in several cells types such as SH-SY5Y neuroblastoma cells, primary hepatocytes, microglia and astrocytes, to name a few (Toyama et al., 2007; Wang et al., 2009; Ni et al., 2011; Culbreth et al., 2017). Here, GCLC is linked to neuroblastoma.